CHEK2 1100delC mutation is frequent among Russian breast cancer patients
Elena V Chekmariova1, Anna P Sokolenko, Konstantin G Buslov
1N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.
Breast Cancer Research and Treatment
|June 8, 2006
Abstract:
This study was aimed to assess the role of CHEK2 1100delC mutation in breast cancer (BC) predisposition in Russia. The 1100delC allele was detected in 14/660 (2.1%) unilateral BC cases and in 8/155 (5.2%) patients with the bilateral form of the disease, but only in 1/448 (0.2%) middle-aged control females and in none of 373 elderly tumor-free women. The obtained data point at potentially high clinical relevance of CHEK2 1100delC testing in females of Russian origin and warrant similar case-control studies in ethnically and geographically related regions, especially in Ukraine, Belarus and Baltic countries.
