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Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
Published on: December 1, 2011
Quasispecies as predictive response factors for antiviral treatment in patients with chronic hepatitis C
Javier Salmerón1, Paloma Muñoz De Rueda, Angela Ruiz-Extremera
1Gastroenterology Unit, Hospital Universitario "San Cecilio,", Granada, Spain. fsalmero@ugr.es
Abstract:
The object of this study was to evaluate the viral factor, especially the quasispecies, as predictive of sustained virologic response. We studied the quasispecies, genotype, viral load, and hepatitis C (HCV) cAg in 41 patients with chronic hepatitis C treated with interferon and in 84 with interferon and ribavirin. In the interferon group, responders presented a lower viral load. From logistic regression analysis of patients treated with interferon plus ribavirin, independent predictors for sustained virologic response were genotype 3a, a low baseline viral load and
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