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Celiac disease prevalence in Brazilian dilated cardiomyopathy patients

Ricardo Schmit T De Bem1, Shirley Ramos Da Ro Sa Utiyama, Renato Mitsunori Nisihara

  • 1Service of Gastroenterology and Digestive Endoscopy, Clinical Hospital, Federal University of Paraná, Curitiba, Paraná, Brazil. ricsdebem@netpar.com.br

Digestive Diseases and Sciences
|June 8, 2006
PubMed

Insights

Screening for celiac disease (CD) in heart transplant candidates with advanced cardiomyopathy (CM) is recommended. The IgA-EmA test is the preferred method for detecting CD in these patients.

Area of Science:

  • Gastroenterology
  • Cardiology
  • Immunology

Background:

  • Celiac disease (CD) is a permanent gluten intolerance associated with autoimmune disorders.
  • A link between CD and dilated cardiomyopathy (CM) has been observed in Europe and the US.
  • The prevalence of CD in South Brazilian patients with advanced CM awaiting heart transplantation is unknown.

Purpose of the Study:

  • To determine the prevalence of celiac disease (CD) in South Brazilian patients with advanced cardiomyopathy (CM) on the heart transplant waiting list.

Main Methods:

  • 74 patients awaiting heart transplantation were evaluated for CD.
  • Serological testing included IgA-EmA (indirect immunofluorescence) and IgA anti-h-tTG (ELISA).
  • Positive patients underwent upper endoscopy with intestinal biopsy for histologic confirmation.

Main Results:

  • IgA-EmA was positive in 2.63% of patients; IgA anti-h-tTG was positive in 6.75%.
  • One patient (1.35%) tested positive for both antibodies.
  • Histologic confirmation of CD was achieved only in IgA-EmA positive individuals.

Conclusions:

  • The study suggests screening for celiac disease (CD) in patients with cardiomyopathy (CM).
  • The IgA-EmA test is recommended as the primary screening method for CD in this population.
  • Early detection of CD may be crucial for managing patients with advanced CM.

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