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Importance of histamine for seizure susceptibility
R Scherkl1, A Hashem, H H Frey
1Department of Pharmacology and Toxicology, School of Veterinary Medicine, Free University of Berlin.
Agents and Actions. Supplements
|January 1, 1991
Abstract:
The influence of drugs affecting the turnover of histamine in brain and histamine antagonists on pentetrazole seizure threshold in mice was studied. A rise in histamine brain concentration as well as treatment with central acting H1-, but not H2- and H3-antagonists led to an increase of the convulsive threshold. It is therefore concluded that histamine has a certain anticonvulsant effect which is mediated through H1-receptors.