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[Dynamic effects of gallium chloride on osteoporotic rat model induced by tretinoin]
Xiao-xia Dai1, Yong-min Xiong, Xiong Guo
1Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
Objective:
To investigate the effect of gallium salts on bone metabolism in osteoporosis rats caused by tretinoin.
Methods:
After duplicating osteoporotic model of rats by using tretinoin, we observed the metabolism of blood, urine and bone in vivo. The rats were divided into control group, osteoporosis group, estrogen treated and gallium chloride treated group. The indexes of bone metabolism and related indexes in serum and urine were observed after 60 days of treatment. In the same time, we observed the dynamic effect of 30 days and 60 days of treatment.
Results:
After duplicating osteoporotic model, rats' bone structures were injured, the bone mineral density and the organic matrix decreased, the contents of tartrate-resistant acid phosphatase (TRAP) in serum were higher. After gallium salt treating, the above damages were inhibited or retarded. Trabecular width and thickness of bone cortex were significantly increased. AKP and TRAP activities were decreased to the level close to that of the control group.
Conclusion:
Gallium salt is effective in treating osteoporosis.
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