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Updated: Aug 8, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
[Design, synthesis and insulin-sensitizing activity of indole derivatives]
Lei Tang1, Yu-she Yang, Ru-yun Ji
1School of Pharmacy, Guiyang Medical College, China. tlei1974@hotmail.com
Aim:
To design and synthesize compounds with insulin-sensitizing activity.
Methods:
Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells.
Results:
One of the synthesized compounds showed strong insulin-sensitizing activity in vitro.
Conclusion:
This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.
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