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Thyroid autoimmunity in children with coexisting type 1 diabetes mellitus and celiac disease: a multicenter study

Z Sumnik1, O Cinek, N Bratanic

  • 1Department of Pediatrics, 2nd Faculty of Medicine, Prague, Czech Republic. zdenek.sumnik@Lfmotol.cuni.cz

Journal of Pediatric Endocrinology & Metabolism : JPEM
|June 9, 2006
PubMed

Insights

Thyroid autoimmunity (TAI) is not more common in children with type 1 diabetes mellitus (DM1) and celiac disease (CD). TAI does not worsen diabetes control in these children.

Area of Science:

  • Pediatric Endocrinology
  • Autoimmune Diseases
  • Metabolic Disorders

Background:

  • Children with type 1 diabetes mellitus (DM1) have an increased risk of thyroid autoimmunity (TAI).
  • TAI is also more prevalent in children with celiac disease (CD).

Purpose of the Study:

  • To investigate the frequency of TAI in children with coexisting DM1 and CD compared to those with DM1 alone.
  • To assess the impact of TAI on the clinical course of DM1 in children.

Main Methods:

  • A multicenter retrospective case-control study.
  • Compared 84 diabetic children with CD to 167 diabetic children without CD, matched for age at DM1 onset, DM1 duration, and study center.
  • Monitored TAI markers, thyroid function, and HbA1c levels.

Main Results:

  • TAI was diagnosed in 13% of children with DM1 and CD, versus 19% in children with DM1 only (not statistically significant).
  • Concomitant TAI did not influence diabetes control (HbA1c) in either group.

Conclusions:

  • The presence of celiac disease does not increase the occurrence of thyroid autoimmunity in children with type 1 diabetes.
  • Thyroid autoimmunity does not negatively affect metabolic control in children with type 1 diabetes mellitus.
Abstract

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