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Approximate variance for a standardized composite measure of linkage disequilibrium
D C Hamilton1, Q Liu, D E C Cole
1Department of Mathematics and Statistics, Dalhousie University, Halifax, Canada.
Abstract:
The approximate variance for the standardized measure of gametic linkage disequilibrium has been described. However, this approach assumes knowledge of the phase of double heterozygotes or Hardy-Weinberg equilibrium. Here we give the approximate variance for a composite measure of linkage disequilibrium which depends only on genotype frequencies. We show by simulation that this variance approximation is valid over a range of allele probabilities and departures from Hardy-Weinberg equilibrium.
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