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Published on: June 3, 2016

Circulating adipocytokines in non-diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic

F Celi1, V Bini, F Papi

  • 1Department of Medical-Surgical Specialties and Public Health, Section of Paediatrics, University of Perugia, Perugia, Italy.

Diabetic Medicine : a Journal of the British Diabetic Association
|June 9, 2006
PubMed

Insights

Type 1 diabetes mellitus alters children's adipocytokine levels, with changes varying by specific cytokine. Factors like puberty, insulin dosage, and glycemic control significantly impact these levels.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Adipose Tissue Biology

Background:

  • Adipocytokines are crucial signaling molecules produced by adipose tissue.
  • Altered adipocytokine profiles are implicated in metabolic diseases, including diabetes.
  • Understanding these changes in pediatric Type 1 diabetes is vital for managing complications.

Purpose of the Study:

  • To investigate the impact of Type 1 diabetes mellitus (T1DM) on circulating adipocytokine levels in children.
  • To explore correlations between adipocytokines and clinical parameters in pediatric T1DM.

Main Methods:

  • Measured serum concentrations of leptin, adiponectin, resistin, and tumor necrosis factor-alpha (TNF-α).
  • Included 91 children with T1DM and 91 healthy controls, aged 11.1 ± 2.7 years.
  • Analyzed data considering pubertal status, insulin dose, and glycemic control (HbA1c).

Main Results:

  • Body mass index-adjusted leptin was higher in pubertal diabetic children; correlated positively with insulin dose.
  • Adiponectin was higher in prepubertal diabetic children; associated with HbA1c.
  • Resistin levels differed by pubertal status and diabetes, while TNF-α showed no significant difference between groups.

Conclusions:

  • Circulating adipocytokine concentrations are dysregulated in children with Type 1 diabetes.
  • The specific changes in adipocytokines are cytokine-dependent.
  • Pubertal development, insulin therapy, and glycemic control are key influencers of adipocytokine levels in pediatric T1DM.
Abstract

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