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Updated: Jul 21, 2026
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 3, 2013
Prognostic factors in prostate cancer.
A Buhmeida1, S Pyrhönen, M Laato
1Departments of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland. abuhme@utu.fi
Diagnostic Pathology
|June 9, 2006
Summary
Gleason score, PSA, and aneuploidy are key indicators for predicting prostate cancer progression and survival. Research highlights these factors for organ-confined and advanced disease, guiding treatment decisions.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Prognostic factors are crucial for predicting survival and progression in prostate cancer.
- Several biomarkers have been investigated for their prognostic significance in different stages of the disease.
Purpose of the Study:
- To identify and summarize the most significant prognostic factors for survival and progression in organ-confined, locally advanced, and advanced prostate cancer.
Main Methods:
- Review and synthesis of published research on prognostic factors in prostate cancer.
- Analysis of biomarkers including Gleason score, tumor volume, surgical margins, Ki-67, p53, PSA, microvessel density, and aneuploidy.
Main Results:
- Gleason score, tumor volume, surgical margins, and Ki-67 index are significant for organ-confined disease survival.
- PSA, Gleason score, stage, capsular invasion, microvessel density, and aneuploidy are key predictors of progression.
- For advanced prostate cancer, Gleason score and nuclear morphometry are highly significant progression predictors.
Conclusions:
- Gleason score, capsular invasion, blood PSA, stage, and aneuploidy are the most reliable markers for progression in organ-confined prostate cancer.
- While other biological markers show promise, their clinical relevance is still under investigation.
- Compound prognostic factors and gene expression profiles offer future potential but require further clinical data.
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