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World collaborative report on in vitro fertilization, 2000.

1, G David Adamson, Jacques de Mouzon

  • 1Fertility Physicians of Northern California, Palo Alto, California 94301, USA. info@fpnc.com

Fertility and Sterility
|June 9, 2006
PubMed
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The 2000 World Report on assisted reproductive technology shows significant differences in live birth rates across 49 countries. It details success rates for in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), highlighting variations by procedure type and patient age.

Area of Science:

  • Reproductive Medicine
  • Public Health
  • Biostatistics

Background:

  • Assisted reproductive technology (ART) utilization varies globally.
  • Monitoring ART outcomes is crucial for public health and clinical practice.
  • The 7th World Report provides a comprehensive analysis of ART data from 2000.

Purpose of the Study:

  • To analyze global variations in live and multiple birth rates from ART procedures.
  • To examine the impact of ART type, patient age, and embryo transfer numbers on outcomes.
  • To estimate the total number of ART-conceived births worldwide.

Main Methods:

  • Analysis of data from 49 countries and six regions for the year 2000.
  • Categorization of ART procedures including conventional in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), egg donation, and frozen embryo transfer (ET).

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  • Statistical examination of live birth rates, multiple birth rates, and factors influencing these outcomes.

    • Main Results:

    • Over 460,000 ART procedures were analyzed.
    • Delivery rates per aspiration: conventional IVF (18.6%), ICSI (20.4%).
    • Delivery rates per transfer: egg donation (32.3%), frozen ET (12.0%).
    • Twin rates for conventional IVF and ICSI were 26.9% and 26.2%, respectively.
    • Triplet rates for conventional IVF and ICSI were 2.8% and 2.9%, respectively.
    • Estimated 197,000 to 220,000 ART-conceived babies born worldwide in 2000.

    Conclusions:

    • Significant international disparities exist in ART live and multiple birth rates.
    • ART success rates vary considerably by procedure type and clinical factors.
    • The report underscores the need for standardized monitoring and reporting of ART outcomes globally.