Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostate cancer: how much do we know and how do we know it?

K P Kleinman1, J B McKinlay

  • 1Harvard Medical School, Boston, Massachusetts 02215, USA.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|June 9, 2006
PubMed
Summary

This study assessed prostate cancer risk factors using the Massachusetts Male Aging Study. Immutable factors like age contribute most to risk, suggesting a focus on these for screening and interventions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal experiences of racial discrimination and child weight status in the first 3 years of life.

Journal of developmental origins of health and disease·2014
Same author

Do community-level predictors of pneumococcal carriage continue to play a role in the conjugate vaccine era?

Epidemiology and infection·2013
Same author

The accuracy of substitution rules for health risk appraisals.

American journal of health promotion : AJHP·2011
Same author

Accounting for racial/ethnic variation in bone mineral content and density: the competing influences of socioeconomic factors, body composition, health and lifestyle, and circulating androgens and estrogens.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2011
Same author

Using encounters versus episodes in syndromic surveillance.

Journal of public health (Oxford, England)·2009
Same author

Relative contributions of multiple determinants to bone mineral density in men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2009

Area of Science:

  • Urology
  • Epidemiology
  • Biostatistics

Background:

  • Prostate cancer risk assessment relies on identifying contributing factors.
  • Quantifying the impact of known risk factors is crucial for effective screening and prevention strategies.

Purpose of the Study:

  • To approximate current knowledge on prostate cancer risk factors.
  • To evaluate the relative contributions of various risk factors to prostate cancer.

Main Methods:

  • Utilized data from the Massachusetts Male Aging Study.
  • Employed logistic regression with 30 identified risk factors.
  • Assessed overall knowledge using Area Under the Receiver Operating Characteristic Curve (AUROC) and Hosmer-Lemeshow statistic.
  • Measured relative contributions using adjusted generalized R2 (AR2) by removing risk factor groups.

Related Experiment Videos

Main Results:

  • The overall model demonstrated adequate fit (AUROC=0.788, p-value for Hosmer-Lemeshow=0.926).
  • Immutable factors (age, genotype) accounted for 42% of the risk.
  • Dietary factors contributed 30%, other lifestyle factors 15%, and endocrinological factors 11%.

Conclusions:

  • While significant knowledge exists, unknown prostate cancer risk factors likely remain.
  • Immutable factors are the most significant contributors to prostate cancer risk.
  • Future interventions should prioritize nutritional behavior and focus screening on age and other unchanging factors.