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Peripheral benzodiazepines potentiate the effect of adenosine in rat vas deferens
E Escubedo1, J Camarasa, M Pallas
1Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Spain.
The Journal of Pharmacy and Pharmacology
|January 1, 1991
Abstract:
Ro 5-4864, diazepam, clonazepam and PK 11195 inhibit the responses of rat was deferens following electrical stimulation in the rank order Ro 5-4864 greater than PK 11195 = diazepam greater than clonazepam. The adenosine-inhibited electrically-induced response was potentiated by Ro 5-4864 or diazepam, but not by clonazepam or PK 11195. This potentiation is due to an inhibition of the adenosine uptake system.