Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Avoidance learning during antidepressant withdrawal in mice.

M Sansone1, M Battaglia, J Ekblom

  • 1Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.

The Journal of Pharmacy and Pharmacology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells.

Molecular and cellular endocrinology·2014
Same author

Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2008
Same author

An endogenous neuroprotectant substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), prevents the behavioral and neurochemical effects of cocaine reinstatement in drug-dependent rats.

Journal of neural transmission (Vienna, Austria : 1996)·2006
Same author

Precision and accuracy of pest and pathogen damage assessment in young eucalypt plantations.

Environmental monitoring and assessment·2005
Same author

Observation of a broad structure in the pi+ pi- J/psi mass spectrum around 4.26 GeV/c2.

Physical review letters·2005
Same author

Measurement of time-dependent CP asymmetries and the CP-odd fraction in the decay B0-->D*+D*-.

Physical review letters·2005
Same journal

Norisoboldine suppresses epithelial-mesenchymal transition in colorectal cancer by simultaneously inhibiting the CXCR4/CXCR7 chemokine receptors and the JAK/STAT3 signaling pathway.

The Journal of pharmacy and pharmacology·2026
Same journal

Development, characterization, and therapeutic evaluation of uniform dezocine-loaded PLGA microspheres for sustained analgesia and cognitive protection.

The Journal of pharmacy and pharmacology·2026
Same journal

Phytochemical constituents, biological activities, toxicological profiles, and current applications of Muntingia calabura L.: an updated review.

The Journal of pharmacy and pharmacology·2026
Same journal

Uterine relaxant effects of Ageratum conyzoides essential oil: influence of hormonal status and calcium modulation.

The Journal of pharmacy and pharmacology·2026
Same journal

Liraglutide-mediated protection against ethanol-induced gastric ulcer in male and female rats: enhancement of mucosal defense, anti-inflammatory and antioxidant mechanism.

The Journal of pharmacy and pharmacology·2026
Same journal

Exploring the mechanism of action of Qufengzhitong pills in treating rheumatoid arthritis via the PI3K/AKT, NF-κB, and MAPK pathways.

The Journal of pharmacy and pharmacology·2026
See all related articles

Withdrawal from desipramine, but not mianserin, enhanced avoidance learning in mice. This effect correlated with increased alpha-adrenoreceptor density, suggesting a neurochemical basis for antidepressant withdrawal phenomena.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Antidepressant medications like desipramine and mianserin are widely used, but their effects during withdrawal are not fully understood.
  • Previous research suggests potential behavioral and neurochemical alterations following cessation of antidepressant treatment.

Purpose of the Study:

  • To investigate the behavioral and neurochemical changes during withdrawal from chronic desipramine or mianserin treatment in mice.
  • To assess the impact of antidepressant withdrawal on shuttle-box avoidance acquisition, locomotor activity, and cerebral cortex adrenoreceptor density.

Main Methods:

  • CD-1 mice received daily injections of desipramine or mianserin (10 mg/kg) for 5 or 14 days.
  • Behavioral testing (shuttle-box avoidance, locomotor activity) and neurochemical analysis (adrenoreceptor density) were performed at various time points post-withdrawal.

Related Experiment Videos

  • Specific focus on alpha- and beta-adrenoreceptor density in the cerebral cortex.

    • Main Results:

    • Withdrawal from mianserin did not induce significant behavioral or neurochemical changes.
    • Mice withdrawn from desipramine showed facilitated avoidance learning when tested 24 hours after the last injection.
    • Desipramine withdrawal led to an upregulation of alpha-2 and, to a lesser extent, alpha-1 adrenoreceptors at 72 hours, without affecting beta-adrenoreceptors or locomotor activity.

    Conclusions:

    • Chronic desipramine treatment, unlike mianserin, can induce behavioral changes during withdrawal, specifically enhanced avoidance learning.
    • The observed avoidance facilitation is potentially linked to the neurochemical adaptations in the central nervous system, particularly the upregulation of alpha-adrenoreceptors.
    • Further research is needed to elucidate the precise role of these neurochemical changes in the behavioral effects of antidepressant withdrawal.