Cyanoacrylate adhesive provides efficient local drug delivery

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Musculoskeletal Therapeutics

Background:

• Biodegradable implants are crucial for musculoskeletal treatments but often costly and unavailable.
• N-butyl-2-cyanoacrylate, a common tissue adhesive, is investigated as an alternative drug-trapping material.
• Absorbable gelatin sponge serves as a scaffold for the drug-eluting implant.

Purpose of the Study:

• To evaluate n-butyl-2-cyanoacrylate as an inexpensive, biodegradable scaffold for local drug delivery.
• To assess the in vitro and in vivo drug release kinetics of vancomycin from the proposed implant.
• To determine the local inflammatory response associated with the n-butyl-2-cyanoacrylate implant in vivo.

Main Methods:

• A mouse muscle pouch model was utilized for in vivo drug release and inflammatory response studies.
• Vancomycin release was quantified using fluorescence polarization immunoassay.
• Inflammatory response was assessed via leukocyte count and a grading system.

Main Results:

• The n-butyl-2-cyanoacrylate implant demonstrated sustained vancomycin release up to 42 days in vitro and 14 days in vivo.
• A local inflammatory response was observed, which diminished over 3 weeks in groups with lower adhesive concentrations.
• The material effectively traps and facilitates slow drug release, indicating potential as a biodegradable drug delivery device.

Conclusions:

• N-butyl-2-cyanoacrylate shows potential as a cost-effective and accessible biodegradable material for local drug delivery in musculoskeletal applications.
• The developed implant offers prolonged drug release, addressing limitations of current systems.
• Further research into optimizing adhesive concentration can mitigate inflammatory responses, enhancing clinical applicability.