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Towards biochips using microstructured optical fiber sensors.

Lars Rindorf1, Poul Erik Høiby, Jesper Bo Jensen

  • 1COM.DTU, Department of Communication, Optics and Materials, Technical University of Denmark, 2800, Kongens Lyngby, Denmark. lhr@com.dtu.dk

Analytical and Bioanalytical Chemistry
|June 9, 2006
PubMed
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This study introduces microstructured optical fiber (MOF) biochips for DNA detection. The novel optic-fluidic chip enables sensitive, low-volume DNA analysis using hybridization and evanescent-wave sensing.

Area of Science:

  • Biophotonics
  • Optoelectronics
  • Molecular Diagnostics

Background:

  • Microstructured optical fibers (MOFs) offer unique light-matter interaction properties.
  • Biochip technology requires miniaturization and high sensitivity for disease detection.
  • Integrating optical fibers into microfluidic systems presents fabrication challenges.

Purpose of the Study:

  • To develop and demonstrate the first biochip incorporating a microstructured optical fiber (MOF).
  • To enable continuous liquid flow control and simultaneous optical characterization within the MOF.
  • To achieve highly selective DNA detection using a functionalized MOF within an optic-fluidic chip.

Main Methods:

  • Fabrication of a PMMA polymer optic-fluidic coupler chip using CO(2) laser ablation.

Related Experiment Videos

  • Functionalization of the MOF's internal surfaces with a DNA-complementary sensing layer.
  • Utilizing the evanescent-wave sensing principle for optical detection of DNA hybridization.
  • Integration of the MOF into a microfluidic system for controlled sample delivery.

    • Main Results:

    • Successful integration of a 16-mm MOF into a functional biochip.
    • Demonstration of continuous liquid flow control and simultaneous optical analysis.
    • Highly selective detection of single-stranded DNA through hybridization.
    • Achieved analysis of sample volumes as low as 300 nL.

    Conclusions:

    • The developed MOF-based biochip represents a novel platform for sensitive and selective DNA detection.
    • The optic-fluidic integration allows for miniaturized, portable diagnostic devices.
    • This technology holds promise for low-volume, high-sensitivity molecular diagnostics.