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[Correlation of expressions of ER and CD59 in Buerger disease]
Jing-yu Deng1, Shi De, Sheng He
1Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Insights
Buerger disease involves altered expression of ER, CD59, and IgG in arterial vessels. CD59 and ER levels increase, while IgG expression varies, suggesting potential roles in disease pathogenesis.
Area of Science:
- Vascular Biology
- Immunology
- Pathophysiology
Background:
- Buerger disease is a rare inflammatory condition affecting small and medium-sized arteries, primarily in the limbs.
- Understanding the molecular mechanisms underlying Buerger disease is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the expression patterns of Estrogen Receptor (ER), CD59, and Immunoglobulin G (IgG) in arterial vessels of Buerger disease patients.
- To determine the correlations between the expression levels of ER, CD59, and IgG in the context of Buerger disease.
Main Methods:
- Immunohistochemistry staining was employed to detect ER, CD59, and IgG expression.
- Arterial vascular endothelial cells from 30 male Buerger disease patients and 30 healthy males were analyzed.
Main Results:
- Estrogen Receptor (ER) and CD59 expression levels were significantly higher in the Buerger disease group compared to the control group (P<0.05).
- Immunoglobulin G (IgG) expression was lower on the arterial intima but higher beneath the intima in the Buerger disease group (P<0.05).
- Spearman rank correlation analysis revealed significant correlations between CD59 and IgG expression, as well as between ER and IgG expression in Buerger disease patients.
Conclusions:
- The study indicates that CD59 and ER expression are upregulated in Buerger disease arterial vessels.
- These findings suggest a potential role for ER and CD59 in the pathophysiology of Buerger disease.
- The observed correlations highlight the intricate interplay between ER, CD59, and IgG in the disease process.
Objective:
To inquire into the expression conditions of ER, CD59 and IgG in Buerger disease arteria vessels and probe their correlation.
Methods:
Two groups of arteria vascular endothelial cells were investigated. The cells in Buerger group were derived from 30 male Buerger disease patients; the cells in the other group were derived from 30 normal men. The levels of ER, CD59 and IgG expression were detected by immunohistochemistry staining.
Results:
The levels of ER and CD59 expression in Buerger disease group were higher than those of control group (P<0.05); the level of IgG expression on arteria intima in Buerger group was lower than that of control group (P<0.05); the level of IgG expression under arteria intima in Buerger group was higher than that of control group (P<0.05). Spearman rank correlation analysis of the Buerger group showed that ZD59 expression and IgG expression are significantly correlated and ER expression and IgG expression are significantly correlated, too.
Conclusion:
The expressions of CD59 and ER are up-regulated, which are probably
