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Updated: Aug 7, 2026
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Myopia in preterm children at 12 to 24 months of age
Sule Ziylan1, Didem Serin, Safak Karslioglu
1Sisli Etfal Hospital, Istanbul, Turkey.
Insights
Axial length is the primary factor influencing myopia development in preterm infants aged 12-24 months. The degree of myopia correlates with axial length and anterior chamber depth, highlighting key biometric influences.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Developmental Biology
Background:
- High incidence of myopia observed in preterm children.
- Understanding biometric factors is crucial for early intervention.
Purpose of the Study:
- Examine biometric factors influencing myopia in preterm children (12-24 months).
- Investigate the role of axial length, lens thickness, and anterior chamber depth.
Main Methods:
- A-scan ultrasonography used to measure ocular biometric parameters.
- Compared preterm myopic children, preterm emmetropic children, and full-term controls.
- Study included 25 myopic, 35 emmetropic preterm children, and 20 full-term controls.
Main Results:
- Significantly greater axial length in the myopic preterm group compared to controls.
- No significant differences in lens thickness or anterior chamber depth among groups.
- Myopia severity increased with longer axial length and shallower anterior chamber depth.
Conclusions:
- Axial length is the main driver of myopia development in preterm infants.
- Axial length and anterior chamber depth influence the degree of myopia.
- Axial length is a critical refractive component in early-onset myopia in preterm populations.
Purpose:
To examine biometric factors that may influence the high incidence of myopia in pre-term children at 12 to 24 months of age.
Patients And Methods:
Fifty eyes of 25 patients with myopia and 70 eyes of 35 patients with emmetropia at 12 to 24 months of age were selected from a group of preterm children who had been screened for retinopathy of prematurity and returned for follow-up examinations. Forty eyes of 20 full-term children of the same age were also included in the study as a control group. A-scan ultrasonography was performed to measure axial length, lens thickness, and anterior chamber depth in the three groups.
Results:
The myopic group had a significantly greater axial length than did the other groups. However, the three groups did not differ in lens thickness or anterior chamber depth. The degree of myopia increased with the increase in axial length and the decrease in anterior chamber depth.
Conclusions:
The development of myopia in preterm children 12 to 24 months of age appears to be influenced mainly by axial length, whereas the degree of myopia seems to be related to axial length and anterior chamber depth. Among refractive components, axial length plays a major role in myopia occurring at this age in preterm patients.
