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Related Experiment Videos

Myeloma in young age.

Usha1, Neeta Agarwal, Prachi Kumar

  • 1Department of Pathology, UGC Advanced Immunodiagnostic Training & Research Centre, Institute of Medical Sciences, Banaras Hindu University, Varanasi.

Indian Journal of Pathology & Microbiology
|June 10, 2006
PubMed
Summary

Multiple myeloma in young adults (<40 years) occurs more frequently in India. This cancer presents similarly to adult myeloma but is predominantly IgG type, with a higher incidence of solitary plasmacytoma.

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Area of Science:

  • Hematology
  • Oncology
  • Epidemiology

Background:

  • Multiple myeloma is a cancer of plasma cells.
  • While typically affecting older adults, rare cases occur in younger individuals.

Purpose of the Study:

  • To investigate the frequency and clinical characteristics of multiple myeloma in young adults in India.
  • To compare young adult myeloma cases with adult myeloma presentations.

Main Methods:

  • Retrospective analysis of 14 myeloma cases in individuals under 40 years old.
  • Review of clinical presentations, radiological findings, and myeloma typing (IgG, IgA, light chain).

Main Results:

  • Young adult myeloma occurred in 14 out of 178 cases (1993-1999).

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  • Clinical symptoms (backache, bone pain, weakness) and radiological findings (lytic lesions, fractures) mirrored adult myeloma.
  • Predominantly IgG myeloma (10/14 cases) and increased solitary plasmacytoma frequency were observed.

    • Conclusions:

    • Multiple myeloma in young Indian adults occurs with notable frequency.
    • Clinical and serological profiles are similar to adult myeloma, with a predominance of IgG type.
    • A higher incidence of solitary plasmacytoma is noted in this age group.