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Updated: Aug 7, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
Optical properties of wounds: diabetic versus healthy tissue
Elisabeth S Papazoglou1, Michael S Weingarten, Leonid Zubkov
1School of Biomedical Engineering and Science, Drexel University, Philadelphia, PA 19104, USA. elisabeth.s.papazoglou@drexel.edu
Abstract:
Diffuse photon density wave (DPDW) methodology at Near Infrared frequencies has been used to calculate absorption and scattering from wounds of healthy and diabetic rats. The diffusion equation for semi-infinite media is being used for calculating the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain device. Differences observed during the course of healing in the two populations can be correlated to the delayed healing observed in diabetics. These results are encouraging and further work will focus on the implementation of this device to the clinical setting as a monitoring tool in chronic diabetic wounds.
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