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[Striatal dopamine transporter density decrease in first episode schizophrenic patients treated with risperidone].

J J Mateos1, F Lomeña, E Parellada

  • 1Servicio de Medicina Nuclear, Hospital Clínico de Barcelona, Universidad de Barcelona, España. 32395jmf@comb.es

Revista Espanola De Medicina Nuclear
|June 10, 2006
PubMed
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First-episode schizophrenia patients treated with risperidone show reduced dopamine transporter binding in the striatum. This finding, assessed using 123I-FP-CIT SPECT, may be linked to schizophrenia or the antipsychotic medication.

Area of Science:

  • Neuroscience
  • Radiology
  • Psychiatry

Background:

  • Extrapyramidal symptoms (PS) are common antipsychotic side effects, but also occur in antipsychotic-naive schizophrenia patients.
  • 123I-FP-CIT SPECT can differentiate degenerative from non-degenerative PS, making it useful for assessing presynaptic dopamine neuron function.

Purpose of the Study:

  • To determine dopamine transporter (DAT) binding in first-episode schizophrenia patients.
  • To investigate the functional state of presynaptic dopamine neurons in this patient group.

Main Methods:

  • An open, transversal study involving 30 schizophrenia patients and 15 healthy controls.
  • 123I-FP-CIT SPECT imaging was used to assess DAT binding.
  • Semi-quantitative analysis of SPECT images focused on striatal regions (caudate nucleus, putamen).

Related Experiment Videos

Main Results:

  • Schizophrenia patients exhibited significantly lower whole striatum 123I-FP-CIT binding ratios compared to healthy subjects.
  • Reduced binding was observed in the whole putamen and its anterior, medium, and posterior regions, but not the caudate nucleus.
  • Female subjects showed higher binding ratios than males, with no correlation found between binding ratios and clinical symptom scales.

Conclusions:

  • First-episode schizophrenia patients treated with risperidone demonstrate decreased striatal DAT binding.
  • This reduction in DAT binding could be attributed to the underlying schizophrenia or be a consequence of risperidone treatment.