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Rourinoside and rouremin, antimalarial constituents from Rourea minor
Zhen-Dan He1, Cui-Ying Ma, Ghee Teng Tan
1Program for Collaborative Research in the Pharmaceutical Sciences, M/C 781, Department of Medical Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, USA.
Abstract:
Bioassay-directed fractionation of the antimalarial active CHCl(3) extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to isolation of two glycosides, rourinoside (1) and rouremin (2), as well as five known compounds, 1-(26-hydroxyhexacosanoyl)-glycerol (3), 1-O-beta-D-glucopyranosyl-(2S,3R,4E-8Z)-2-N-(2'-hydroxypalmitoyl)-octadecasphinga-4,8-dienine, 9S,12S,13S-trihydroxy-10E-octadecenoic acid, dihydrovomifoliol-9-beta-D-glucopyranoside, and beta-sitosterol glucoside. Compounds 1-3 showed weak in vitro activities against Plasmodium falciparum. Their structures and stereochemistry were elucidated by spectroscopic methods and selected enzyme hydrolysis.
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