Three cases of xanthogranulomatous epididymitis caused by E. coli

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Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
08:30

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns

Published on: December 12, 2025

Taek Won Kang1, Kyung Hwa Lee, Cheng Zhe Piao

  • 1Department of Urology, Chonnam National University Medical School, #5 Hak-dong, Dong-gu, Gwangju, 501-749, Republic of Korea.

The Journal of Infection
|June 10, 2006
PubMed

Insights

Xanthogranulomatous epididymitis, a rare benign condition, is characterized by tissue destruction and foamy macrophages. This study identifies Escherichia coli (E. coli) as a causative pathogen in three cases.

Area of Science:

  • Pathology
  • Microbiology
  • Genitourinary Medicine

Background:

  • Xanthogranulomatous epididymitis is an uncommon benign inflammatory condition.
  • It involves tissue destruction and accumulation of foamy macrophages.
  • Proteus and E. coli are commonly implicated pathogens.

Observation:

  • This study investigated three cases of xanthogranulomatous epididymitis.
  • DNA was microdissected from Hematoxylin and Eosin (H&E) stained slides.
  • Pathogen identification involved 16S rRNA gene sequencing and specific PCR assays.

Findings:

  • Escherichia coli (E. coli) was identified as the causative pathogen in all three cases.
  • Pathogen-specific PCR utilized primer pairs for alr, ipaH, ial, and iuc genes.
  • 16S rRNA sequencing aided in initial pathogen identification.

Implications:

  • This research highlights E. coli's role in xanthogranulomatous epididymitis.
  • Advanced molecular techniques can identify pathogens from H&E slides.
  • Understanding the etiology aids in diagnosis and management of this rare condition.

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