Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats.

C Y Yang1, P D L Chao, Y C Hou

  • 1Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung 404, Taiwan, ROC.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|June 10, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transient Large-Scale Anisotropy in TeV Cosmic Rays due to an Interplanetary Coronal Mass Ejection.

Physical review letters·2026
Same author

First Detection of Ultrahigh Energy Emission from Gamma-Ray Binary LS I +61° 303.

Physical review letters·2026
Same author

Evidence of Cosmic-Ray Acceleration up to Sub-PeV Energies in the Supernova Remnant IC 443.

Physical review letters·2026
Same author

Precise Measurement of the Cosmic Ray Helium Spectrum above 0.1 PeV.

Physical review letters·2026
Same author

[Impact of anti-gp210 and anti-centromere antibody dual positivity on clinical prognosis in patients with primary biliary cholangitis: risk analysis and establishment of response criteria].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2026
Same author

[Establishment of a prediction model and analysis of influencing factors for postoperative infections in esophageal cancer patients].

Zhonghua yi xue za zhi·2026

Ginkgo and onion significantly reduce cyclosporin absorption, decreasing its bioavailability. Avoid taking these quercetin-rich foods with cyclosporin to maintain drug effectiveness.

Area of Science:

  • Pharmacology
  • Drug Metabolism
  • Natural Products

Background:

  • Quercetin influences drug-metabolizing enzymes (CYP isoenzymes) and drug transporters like P-glycoprotein (Pgp).
  • Previous research showed quercetin reduces cyclosporin bioavailability, a substrate for CYP3A4 and Pgp.
  • Ginkgo and onion are sources of quercetin, similar to St. John's Wort, raising concerns about potential drug interactions.

Purpose of the Study:

  • To investigate the impact of ginkgo and onion on the absorption and disposition of cyclosporin in rats.
  • To determine if interactions occur at the absorption site or during systemic circulation.

Main Methods:

  • Rats received oral and intravenous cyclosporin, with and without ginkgo or onion, in a crossover design.
  • Blood cyclosporin concentrations were measured using fluorescence polarization immunoassay.

Related Experiment Videos

  • Everted gut sac experiments assessed the effect on intestinal Pgp function.

    • Main Results:

    • Oral coadministration of ginkgo and onion significantly reduced cyclosporin's maximum concentration (Cmax) by 62% and 60%, and area under the curve (AUC0-t) by 51% and 68%, respectively.
    • No significant effect on cyclosporin disposition was observed after intravenous administration.
    • These findings suggest interactions primarily occur at the intestinal absorption level.

    Conclusions:

    • Ginkgo and onion markedly decrease the oral bioavailability of cyclosporin in rats.
    • The observed interactions are attributed to effects on absorption, likely involving Pgp.
    • Concurrent use of quercetin-rich herbs or foods with cyclosporin should be avoided to ensure therapeutic efficacy.