Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipodermatosclerosis in patients with diffuse connective tissue diseases.

Fernanda Dias Gonzalez1, Fernanda Pedreira Magalhães, Alice Pontes Vilas Boas Freitas

  • 1Núcleo de Reumatologia do Hospital Santa Izabel, Escola Bahiana de Medicina e Saúde Pública-Salvador/ Bahia, Brazil.

European Journal of Internal Medicine
|June 10, 2006
PubMed
Summary

Lipodermatosclerosis (LDS) is a painful leg condition. This study highlights three cases of LDS in patients with diffuse connective tissue diseases (DCTD), emphasizing its recognition for appropriate patient management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus.

The New England journal of medicine·2026
Same author

Long-term persistence of serum IgM antibodies against chikungunya virus in patients with chronic arthralgia.

Virology journal·2025
Same author

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis.

The New England journal of medicine·2025
Same author

Bilateral outer foveal microdefect in a patient with systemic lupus erythematosus using hydroxychloroquine - A case report.

Lupus·2024
Same author

Clinical disease activity index applicability in lupus arthropathy: Unraveling underdiagnosed joint activity.

Lupus·2023
Same author

Lupus Arthropathy: An Evolving Concept.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2023

Area of Science:

  • Dermatology
  • Rheumatology
  • Internal Medicine

Background:

  • Lipodermatosclerosis (LDS) presents as hardened, painful, hyperchromic plaques on the legs.
  • LDS is often associated with venous insufficiency, but its pathogenesis remains unclear.
  • Skin thickening in LDS can mimic scleroderma, posing diagnostic challenges.

Purpose of the Study:

  • To describe the occurrence of lipodermatosclerosis in patients with diffuse connective tissue diseases (DCTD).
  • To underscore the importance of recognizing LDS in DCTD patients.
  • To prevent potential adverse effects from misdirected treatments.

Main Methods:

  • Case series describing three patients with diagnosed diffuse connective tissue diseases.
  • Detailed clinical presentation of lipodermatosclerosis in each patient.

Related Experiment Videos

  • Review of patient histories including associated conditions and previous diagnoses.

    • Main Results:

    • Three patients with distinct DCTD (systemic lupus erythematosus with antiphospholipid syndrome, overlapping DCTD, CREST syndrome with primary biliary cirrhosis) developed lipodermatosclerosis.
    • The clinical presentation of LDS was consistent across these diverse DCTD cases.
    • The skin changes in LDS were noted to be similar to those seen in scleroderma.

    Conclusions:

    • Lipodermatosclerosis can manifest in patients with various diffuse connective tissue diseases.
    • Early and accurate identification of LDS in DCTD patients is crucial for appropriate management.
    • Recognizing LDS can help avoid the potentially harmful use of medications like penicillamine and immunosuppressants.