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[Establishment of a pig model of chronic ally enhanced external counterpulsation]
Xiao-lin Chen1, Xiao-hong He, Yan Zhang
1Department of Cardiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510089, China. cxlmce68@yahoo.com.cn
Objective:
To establish a pig model of chronic external counterpulsation.
Methods:
Twelve pigs were anaesthetized with sodium pentobarbital (< or =30 mg/kg.b.w.) and 846 mixture (< or =0.1 ml/kg.b.w.) and counterpulsed in a lateral position for 2 h every two days (totally 36 h) with 0.025 to 0.04 MPa/cm(2) pressure.
Results:
External counterpulsation was successfully completed in all the animals. Combined administration of sodium pentobarbital and 846 mixture resulted in good anesthetic effect with reduced anesthetic dosage and minimal side effect on the viscera (the liver, kidney and heart, etc).
Conclusion:
The pig model of chronic external counterpulsation has been successfully established. Combined use of sodium pentobarbital and 846 mixture is recommended for chronic external counterpulsation.
