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Updated: Aug 7, 2026
Development and Angiographic Use of the Rabbit VX2 Model for Liver Cancer
Published on: January 7, 2019
[Quantitative study of dynamic magnetic resonance perfusion-weighted imaging in rabbit models of implanted hepatic
Xian-yue Quan1, Xue-lin Zhang, Xi-jie Sun
1Imaging Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. quanxianyue@163.com
Objective:
To investigate the possibility of dynamic magnetic resonance (MR) perfusion-weighted imaging (PWI) in rabbit models of implanted hepatic VX2 tumor.
Methods:
MRI and PWI images were obtained from 16 rabbit models of implanted hepatic VX2 tumor and 4 normal rabbits at 14, 18, 22, and 26 days after tumor implantation, respectively, and the mean time to enhancement (MTE) and maximum slope of increase (MSI) were estimated and compared with pathological changes.
Results:
In the rabbit models of implanted hepatic tumor the MTE tended to increase and MSI to descend 14, 18, 22, and 26 days after tumor implantation, showing significant differences from the control group. Coagulation necrosis and fibrous hyperplasia in the tumors appeared to progress with time as found pathologically.
Conclusion:
Dynamic MR PWI quantitative analysis of rabbit models of implanted hepatic VX2 tumor provides valuable means for observing the growth behaviors of VX2 tumor and may be clinically applicable in the evaluation of hepatic diseases.
