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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs
Hirokazu Tamamura1, Hiroshi Tsutsumi, Hiroyuki Masuno
1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Japan. tamamura.mr@tmd.ac.jp
Abstract:
A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which were previously found to be strong CXCR4 antagonists that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression and rheumatoid arthritis.
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