Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Breast feeding in IMD.

A MacDonald1, E Depondt, S Evans

  • 1Birmingham Children's Hospital, Birmingham, UK. anita.macdonald@bch.nhs.uk

Journal of Inherited Metabolic Disease
|June 10, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The origins of patchy aurora at Jupiter.

Nature communications·2026
Same author

Nutritional profiling of foods for Phenylketonuria.

Scientific reports·2025
Same author

Response to the detection of <i>Rugonectria castaneicola</i> and <i>Rugonectria wingfieldii sp. nov.</i> on <i>Quercus</i> in Australia.

Fungal systematics and evolution·2024
Same author

Revisiting the Profile of Patients with No Fixed Abode Admitted to Psychiatric Inpatient Units, 2017-2021.

Irish medical journal·2023
Same author

Designing rare disease care pathways in the Republic of Ireland: a co-operative model.

Orphanet journal of rare diseases·2022
Same author

The Impact of the New State Body for Transplantation on Lung Transplantation Waiting List Mortality.

Irish medical journal·2020
Same journal

Biallelic Loss-Of-Function Variant in ATP5ME Is Associated With Severe and Early Onset Oxidative Phosphorylation Deficiency.

Journal of inherited metabolic disease·2026
Same journal

Beyond Upper Airway Involvement: Evidence of Intrinsic Lung Disease in a Mouse Model of Mucopolysaccharidosis I.

Journal of inherited metabolic disease·2026
Same journal

Immune Dysregulation in Branched Chain Organic Acidemias.

Journal of inherited metabolic disease·2026
Same journal

Long Term Follow-Up After Transplantation in Propionic Acidemia: A Retrospective French Pediatric and Adult Cohort Study.

Journal of inherited metabolic disease·2026
Same journal

Tri-Parametric Assessment of α-Galactosidase A Activity, lysoGb3 and X-Inactivation Aids Genotype-Phenotype Categorization of Fabry Disease Female Patients.

Journal of inherited metabolic disease·2026
Same journal

Mapping the Severity of Phenylalanine Hydroxylase Deficiency.

Journal of inherited metabolic disease·2026
See all related articles

Breastfeeding can be successful for infants with certain inherited metabolic disorders (IMDs), like MSUD and tyrosinaemia type I, when combined with specialized formulas. However, success varies, and more research is needed for feeding guidelines.

Area of Science:

  • Metabolic Disorders
  • Pediatric Nutrition
  • Clinical Dietetics

Background:

  • Breastfeeding offers known advantages for infants, including those with inherited metabolic disorders (IMDs).
  • Limited data exists on breastfeeding experiences for IMDs beyond phenylketonuria.
  • Established dietary management for IMDs involves specialized infant formulas.

Purpose of the Study:

  • To investigate the feasibility and outcomes of breastfeeding in infants diagnosed with various inherited metabolic disorders.
  • To gather data on current breastfeeding practices and challenges in IMD management.
  • To identify specific IMDs where breastfeeding is successfully implemented.

Main Methods:

  • A global survey was distributed to dietitians and clinicians at 27 Inherited Metabolic Disorders (IMD) centers across 15 countries.

Related Experiment Videos

  • The questionnaire collected data on breastfeeding experiences for over 8000 IMD patients managed with diet.
  • Data focused on successful breastfeeding, feeding protocols, and duration.

    • Main Results:

    • Successful demand breastfeeding, supplemented with precursor-free infant amino acid formula, was reported in infants with Maple Syrup Urine Disease (MSUD), tyrosinaemia type I, and homocystinuria.
    • 89% of these infants remained breastfed at 16 weeks.
    • Fewer infants with organic acidaemias (propionic, methylmalonic, isovaleric) and urea cycle disorders (CPS deficiency) were successfully demand breastfed, often requiring complementary protein-free or precursor-free formulas.

    Conclusions:

    • Demand breastfeeding, alongside specific formulas, is achievable for some infants with IMDs like MSUD and tyrosinaemia type I.
    • Breastfeeding success is less consistent in infants with organic acidaemias and urea cycle disorders.
    • Further research is essential to develop comprehensive feeding guidelines and monitoring protocols for breastfed infants with IMDs.