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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
[Clinical significance of survivin expression in peripheral T-cell lymphoma]
Xiao-Juan Xiang1, You-Jian He, Yu-Hong Li
1State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China. xxjwen@163.com
Background & Objective:
Peripheral T-cell lymphoma (PTCL) accounts for about 10%-15% of non-hodgkin's lymphomas (NHL), usually associated with short clinical course and poor prognosis. The over expression of survivin, a member of inhibitor of apoptotic protein (IAP), is regarded as a poor prognostic index in many malignant tumors. This study was to detect the expression of survivin in PTCL, and analyze its correlation to clinical features and prognosis of PTCL.
Methods:
The expression of survivin in 51 specimens of naive PTCL was detected by immunohistochemistry. The correlations of survivin expression to clinical features and prognosis were analyzed by SPSS10.0 software.
Results:
The positive rate of survivin was 82.3%. Its expression had no significant correlations to sex, age, clinical stage, the number of extranodal lesions, performance status, serum level of lactate dehydrogenase, B symptoms, and international prognostic index (P>0.05). The 5-year overall survival rate of the 51 patients was 32.67%. The patients with positive survivin expression had poorer 5-year overall survival than negative patients (25.0% vs. 75.0%, P=0.03). Cox regression model showed that survivin was an independent poor prognostic index of PTCL.
Conclusions:
Survivin is a useful prognostic index of PTCL. We can screen out the cases which may have poor prognosis early by combining survivin expression with IPI, and improve the treatment outcome of PTCL.
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