Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reflux events and sleep: are we vulnerable?

William C Orr1

  • 1Lynn Health Science Institute, 5300 North Independence, Suite 130, Oklahoma City, OK 73112-4999, USA. worr@lhsi.net

Current Gastroenterology Reports
|June 13, 2006
PubMed
Summary

During sleep, impaired esophageal acid clearance worsens gastroesophageal reflux complications. This review explores how sleep disturbances and daytime issues are linked to reflux, impacting diagnosis and treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peroxiredoxins Play an Important Role in the Regulation of Immunity and Aging in <i>Drosophila</i>.

Antioxidants (Basel, Switzerland)·2023
Same author

Effects of menthol on esophageal motility in humans: Studies using high-resolution manometry.

Neurogastroenterology and motility·2021
Same author

Effects of codeine on esophageal peristalsis in humans using high resolution manometry.

Journal of gastroenterology and hepatology·2021
Same author

Esophageal acid burden in reflux patients with normal endoscopy: Does esophageal peristalsis matter?

Journal of the Formosan Medical Association = Taiwan yi zhi·2021
Same author

Hyperoxidation of Peroxiredoxins and Effects on Physiology of <i>Drosophila</i>.

Antioxidants (Basel, Switzerland)·2021
Same author

Mitochondrial Redox Signaling Is Critical to the Normal Functioning of the Neuronal System.

Frontiers in cell and developmental biology·2021

Area of Science:

  • Gastroenterology
  • Sleep Medicine
  • Physiology

Background:

  • Gastroesophageal reflux disease (GERD) is a common condition.
  • Esophageal acid exposure is a primary factor in GERD complications.
  • Sleep physiology can influence acid reflux events and their consequences.

Purpose of the Study:

  • To review the physiological changes during sleep that affect esophageal acid contact.
  • To examine the link between sleep-related acid reflux and esophagitis.
  • To discuss the impact of sleep disruption on GERD diagnosis and management.

Main Methods:

  • Literature review of studies on sleep and esophageal acid exposure.
  • Analysis of physiological mechanisms altering esophageal clearance during sleep.
  • Synthesis of research on the clinical implications of sleep-related GERD.

Main Results:

  • Sleep impairs esophageal acid clearance, increasing vulnerability to reflux complications.
  • Prolonged acid mucosal contact during sleep contributes to esophagitis.
  • Sleep disruption from reflux leads to daytime sleepiness and reduced performance.

Conclusions:

  • Sleep-related physiological changes significantly impact GERD.
  • Understanding these changes is crucial for effective GERD diagnosis and treatment.
  • Addressing sleep disturbances is important for managing GERD patients.

Related Experiment Videos