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Topooptical investigations and enzymatic digestions on tissue-isolated amyloid fibrils

Josef Makovitzky1, Susann Richter, Thomas R Appel

  • 1Institute of Pathology, Clinic of Gynecology and Obstetrics am Klinikum der Hansestadt Rostock, University of Rostock, Südring 81, D-18059 Rostock, Germany. josef.makovitzky@med.uni-rostock.de

Acta Histochemica
|June 13, 2006
PubMed

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...