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Clinical features associated to refractory obsessive-compulsive disorder.

Ygor A Ferrão1, Roseli G Shavitt, Nádia R Bedin

  • 1Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. ygoraf@terra.com.br

Journal of Affective Disorders
|June 13, 2006
PubMed
Summary

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Treatment-refractory obsessive-compulsive disorder (OCD) is linked to sexual/religious symptoms, low economic status, and significant family accommodation. These factors independently predict poor treatment response in OCD patients.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Obsessive-compulsive disorder (OCD) presents a treatment challenge for some patients who do not respond adequately to existing therapies.
  • Identifying factors associated with treatment-refractoriness is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate clinical variables associated with treatment-refractoriness in obsessive-compulsive disorder (OCD).
  • To compare patients with treatment-refractory OCD against those with treatment-responding OCD.

Main Methods:

  • A case-control study was conducted.
  • 23 patients with treatment-refractory OCD were compared with 26 patients with treatment-responding OCD.

Main Results:

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  • Initial analysis identified higher symptom severity at onset, chronic course, lack of a partner, unemployment, low economic status, sexual/religious symptoms, and high family accommodation as associated with refractoriness.
  • Regression analyses revealed that sexual/religious symptoms, low economic status, and high family accommodation remained significantly associated with treatment-refractoriness.

Conclusions:

  • Sexual/religious symptoms, low economic status, and significant family accommodation are independently associated with treatment-refractoriness in OCD.
  • These factors may serve as predictive indicators for treatment non-response.
  • Further longitudinal studies are recommended to confirm these predictive associations.