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Published on: May 10, 2024
ATM polymorphism IVS62+60G>A is not associated with disease aggressiveness in prostate cancer
Robert E Lee Browning1, Hecheng Li, Eric T Shinohara
1Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Objectives:
ATM is an important protein that protects the genome from double-stranded DNA breaks. Mutations and polymorphisms in the ATM gene have been associated with an increased risk of certain types of malignancies, especially breast cancer.
Methods:
We analyzed tissue from 98 white patients with prostate cancer for the presence of IVS62+60G>A polymorphism in the ATM gene.
Results:
The frequency of the homozygous IVS62+60G/G, heterozygous IVS62+60G/A, and homozygous IVS62+60A/A was 18.37% (18 of 98), 30.61% (30 of 98), and 51.02% (50 of 98), respectively. Using Fisher's exact test, we found the polymorphism IVS62+60G>A was not significantly related to age, tumor grade, prostate-specific antigen level, or clinical stage (P >0.05). No difference was found in relapse-free survival between patients with IVS62+60G/G and those with IVS62+60G/A or IVS62+60A/A (P = 0.4533).
Conclusions:
The results of our study indicate that this ATM polymorphism is not associated with the aggressiveness of prostate cancer in white men.
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