Related Experiment Video

Updated: Aug 5, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Antiphospholipid syndrome and the kidneys

Imad Uthman1, Munther Khamashta

  • 1Division of Rheumatology, Faculty of Medicine, American University of Beirut, Medical Center, Beirut, Lebanon. iuthman@aub.edu.lb

Seminars in Arthritis and Rheumatism
|June 13, 2006
PubMed

Insights

Antiphospholipid antibodies are linked to various kidney diseases, including thrombotic events and glomerulonephritis. Early detection of kidney involvement in antiphospholipid syndrome (APS) can improve patient outcomes.

Area of Science:

  • Nephrology
  • Rheumatology
  • Immunology

Background:

  • Antiphospholipid syndrome (APS) is an autoimmune disorder associated with a prothrombotic state.
  • Renal involvement is a significant complication of APS, impacting both primary and secondary forms.
  • Understanding the spectrum of kidney diseases associated with antiphospholipid antibodies is crucial for patient management.

Purpose of the Study:

  • To investigate the relationship between antiphospholipid antibodies and various kidney diseases.
  • To consolidate knowledge on renal manifestations of APS.
  • To highlight the importance of early diagnosis of renal complications.

Main Methods:

  • Comprehensive literature review of medical studies from 1968 to 2005.
  • Utilized MEDLINE database for relevant research.
  • Keywords included antiphospholipid syndrome, anticardiolipin antibodies, lupus anticoagulant, and various renal pathologies.

Main Results:

  • Renal manifestations stem from thrombosis in arteries, arterioles, glomerular capillaries, and veins.
  • Observed conditions include renal artery stenosis, malignant hypertension, infarction, venous thrombosis, and thrombotic microangiopathy.
  • Glomerulonephritis, a nonthrombotic condition, is also increasingly reported in APS patients.

Conclusions:

  • The kidney is a primary target organ in antiphospholipid syndrome.
  • Early identification of renal involvement is key to improving prognosis.
  • Further research into nonthrombotic renal manifestations is warranted.
Abstract

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...