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Calcium balance in children treated with diphosphonates.
Archives of Disease in Childhood
|March 1, 1975
Summary
Ethane-1-hydroxy-1,1-diphosphonate (EHDP) therapy reduced calcium balance in children with ectopic calcification. This effect, driven by increased fecal calcium excretion, was more pronounced with longer treatment durations.
Area of Science:
- Pediatric Nephrology
- Pharmacology
- Biochemistry
Background:
- Ectopic calcification presents a challenge in pediatric medicine.
- Ethane-1-hydroxy-1,1-diphosphonate (EHDP) is used for treating conditions with ectopic calcification.
Purpose of the Study:
- To evaluate the effect of EHDP on mineral balance in children.
- To investigate EHDP's impact on calcium excretion and absorption.
Main Methods:
- Serial mineral balance studies were conducted in three pediatric patients.
- Calcium balance was monitored during EHDP therapy.
Main Results:
- All patients showed a reduction in overall calcium balance.
- Increased fecal calcium excretion was the primary mechanism for reduced calcium balance.
- The effect on calcium balance was more significant with prolonged EHDP therapy.
Conclusions:
- EHDP therapy can lead to a negative calcium balance in children with ectopic calcification.
- Findings in children contrast with adult studies but align with animal models.
- EHDP may influence calcium absorption, warranting further investigation in pediatric populations.