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Related Experiment Videos

Resonant waveguide grating biosensor for living cell sensing.

Ye Fang1, Ann M Ferrie, Norman H Fontaine

  • 1Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, New York 14831, USA. fangy2@corning.com

Biophysical Journal
|June 13, 2006
PubMed
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Resonant waveguide grating biosensors detect cell responses by monitoring mass redistribution. This study models bradykinin receptor signaling, linking biosensor signals to cellular dynamics for probing living cells.

Area of Science:

  • Biophysics
  • Cell Biology
  • Biosensing Technology

Background:

  • Cellular responses to stimuli involve complex internal dynamics.
  • Optical biosensors offer label-free monitoring of biological processes.
  • Resonant waveguide gratings (RWGs) provide high-sensitivity detection.

Purpose of the Study:

  • To present theoretical analysis and experimental data for RWG biosensors characterizing stimulation-mediated cell responses.
  • To demonstrate RWG biosensors' capability in detecting cellular content redistribution.
  • To develop a mathematical model for bradykinin receptor signaling dynamics.

Main Methods:

  • Utilizing resonant waveguide grating (RWG) biosensors for real-time monitoring.
  • Analyzing optical output parameters: incident angle shifts and resonant peak shape changes.

Related Experiment Videos

  • Developing a mathematical model using ordinary differential equations to describe receptor signaling.

    • Main Results:

    • RWG biosensors differentiate between perpendicular (mass redistribution) and parallel (content inhomogeneity) cellular changes.
    • Observed optical signatures correlate with cell adhesion, spreading, detachment, and receptor-mediated signaling.
    • The mathematical model accurately predicts bradykinin-mediated dynamic mass redistribution (DMR) signals.

    Conclusions:

    • RWG biosensors are effective tools for probing living cell dynamics and signaling.
    • The developed model provides fundamental insights into receptor internalization and protein relocation.
    • This work establishes a basis for using optical biosensors in cell biology research.