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Regulation of stroke-induced neurogenesis in adult brain--recent scientific progress

Zaal Kokaia1, Pär Thored, Andreas Arvidsson

  • 1Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, SE-221 84 Lund, Sweden. Zaal.Kokaia@med.lu.se

Cerebral Cortex (New York, N.Y. : 1991)
|June 13, 2006
PubMed

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...