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The HLA-DRB6 locus defines an evolutionary supratypic group within the DRB family of genes
A Corell1, J M Martin-Villa, P Morales
1Immunologia, Hospital 12 de Octubre, Madrid, Spain.
International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement
|January 1, 1991
Abstract:
A novel DRB gene member has recently been identified (DRB6). It defines a new supratypic group of HLA-DR alleles comprising the DR1-, DR2-, and DRw10-carrying haplotypes. The comparison of this gene either at the nucleotide or at the protein level with other HLA-DRB genes supports its inclusion in the DRB gene family and not in DPB or DQB gene families. Moreover, the construction of an evolutionary gene-tree shows that this gene is probably the eldest member of the DRB gene family. Contradictory expression results do not clarify whether or not DRB6 is a pseudogene.