Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small molecule-based reversible reprogramming of cellular lifespan.

Jaejoon Won1, Mina Kim, Nuri Kim

  • 1Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.

Nature Chemical Biology
|June 13, 2006
PubMed
Summary

Researchers discovered a small molecule, CGK733, that can reverse cellular senescence by selectively targeting ATM and ATR proteins. This finding offers a potential new strategy for extending human cell lifespan and combating age-related diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex differences of clinical outcomes in patients undergoing percutaneous coronary intervention: a nationwide cohort study.

Coronary artery disease·2026
Same author

Higher cardiovascular risk observed with beta-blockers in CKD patients without prior cardiovascular disease.

Clinical kidney journal·2026
Same author

Clinical Outcomes of Contemporary Bariatric Surgical Procedures: A Nationwide Cohort Study.

Journal of obesity & metabolic syndrome·2026
Same author

Clopidogrel Vs Aspirin Monotherapy for Secondary Prevention After Percutaneous Coronary Intervention: A Nationwide Cohort Study.

JACC. Asia·2026
Same author

Systemic cancer risk profile in neovascular age-related macular degeneration: insights into shared aging-related mechanisms from a nationwide population-based study.

Aging·2026
Same author

5-(Benzofuran-2-yl)-3-(2-chloro-4-fluorobenzyl)-1,3,4-oxadiazol-2(3H)-one (GM-90663) Alleviates Dravet Syndrome via Inhibiting Monoamine Oxidase Activity.

Molecules (Basel, Switzerland)·2026

Area of Science:

  • Cellular biology
  • Molecular medicine
  • Aging research

Background:

  • Cellular senescence is a natural process limiting normal human cell lifespan.
  • Identifying molecules to extend cell longevity remains a significant challenge in aging research.

Purpose of the Study:

  • To identify small molecules capable of reversing cellular senescence.
  • To investigate the molecular mechanisms underlying cellular aging and lifespan extension.

Main Methods:

  • High-throughput phenotypic screening with automated imaging to identify potential compounds.
  • Magnetism-based interaction capture (MAGIC) technology to identify molecular targets.
  • siRNA-mediated knockdown to validate target engagement.

Main Results:

Related Experiment Videos

  • CGK733 selectively inhibits ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) kinase activities.
  • CGK733 effectively reverses cellular senescence, resetting the intrinsic 'senescence clock'.
  • siRNA knockdown of ATM and ATR partially induced proliferation of senescent cells, supporting CGK733's mechanism.

Conclusions:

  • CGK733 represents a novel small molecule capable of reversibly modulating the senescence pathway.
  • Targeting ATM and ATR kinase activities offers a promising therapeutic strategy for extending cellular lifespan and potentially treating age-related conditions.