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Leber's hereditary optic neuropathy precipitated by ethambutol
Asako Ikeda1, Tomohiro Ikeda, Naohiro Ikeda
1Department of Ophthalmology, Takarazuka City Hospital, Takarazuka, Japan.
Japanese Journal of Ophthalmology
|June 13, 2006
Summary
Ethambutol may trigger Leber's hereditary optic neuropathy (LHON) in older women. This case highlights the risk of ethambutol in patients with a predisposition to LHON.
Area of Science:
- Ophthalmology
- Genetics
- Pharmacology
Background:
- Leber's hereditary optic neuropathy (LHON) typically affects young males.
- Previous reports suggest ethambutol may induce LHON in older individuals.
Observation:
- A 70-year-old woman developed severe vision loss after starting ethambutol for tuberculosis.
- Genetic analysis revealed the 11778 mitochondrial DNA mutation, characteristic of LHON.
Findings:
- Ethambutol administration is associated with LHON development in susceptible individuals.
- This case represents the fourth reported instance of ethambutol-induced LHON.
Implications:
- Ethambutol should be used cautiously in patients with a family history of LHON.
- Identifying at-risk individuals is crucial to prevent ethambutol-related optic neuropathy.
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