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Related Experiment Videos

A method for single-session cocaine self-administration in the mouse.

Christopher M Olsen1, Danny G Winder

  • 1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232-0615, USA. chris.olsen@vanderbilt.edu

Psychopharmacology
|June 13, 2006
PubMed
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Mice readily self-administer cocaine, demonstrating high drug intake and breakpoints during initial exposure. This progressive ratio method enables rapid cocaine self-administration studies in mice.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Drug self-administration is crucial for assessing drug reinforcement and effects.
  • Existing methods require optimization for rapid studies using genetically modified mice.

Purpose of the Study:

  • To develop a mouse model for high cocaine self-administration upon first drug exposure.
  • To establish a rapid progressive ratio (PR) cocaine self-administration protocol.

Main Methods:

  • C57Bl/6J mice were trained on fixed ratio 1 and progressive ratio (PR) schedules.
  • Intravenous cocaine self-administration was assessed using a PR schedule over 16-hour sessions.
  • Dose-response effects of cocaine (0.1-1.2 mg/kg) and saline were evaluated.

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Main Results:

  • Mice exhibited a strong preference for cocaine over saline, with higher breakpoints and active lever choices.
  • Cocaine self-administration showed a dose-dependent increase in breakpoints and drug intake.
  • Active lever pressing was significantly higher for contingent cocaine self-administration than non-contingent delivery, indicating drug-seeking behavior.

Conclusions:

  • Mice achieve substantial cocaine intake and high breakpoints during initial exposure.
  • This PR self-administration method is efficient for rapid cocaine studies in mice.