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Unusual solubility behaviour of cyclosporin A in aqueous media
G Ismailos1, C Reppas, J B Dressman
1Department of Pharmacy, University of Athens, Greece.
The Journal of Pharmacy and Pharmacology
|April 1, 1991
Abstract:
The solubility of cyclosporin A was determined in water and in Sorensen buffers at pH 1.2 and 6.6 at temperatures ranging from 5 to 37 degrees C. No differences in solubility behaviour were observed among the three aqueous media. Solubility was found to be inversely proportional to the temperature in each medium, indicating that the heat of solution was exothermic in each case.