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Updated: Aug 7, 2026
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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
[Sentinel lymph node detection using 99mTc-nanocolloid in endometrial cancer]
P Dzvincuk1, R Pilka, M Kudela
1Gynekologicko-porodnická klinika FN a LF UP, Olomouc.
Ceska Gynekologie
|June 14, 2006
Summary
Pre-operative lymphoscintigraphy and radio-guided surgery are feasible for identifying sentinel lymph nodes in endometrial cancer patients. This technique accurately detects metastatic nodes, showing no false negatives when representative nodes are analyzed.
Area of Science:
- Oncology
- Nuclear Medicine
- Surgical Oncology
Background:
- Endometrial cancer staging often requires lymph node assessment.
- Sentinel lymph node biopsy is a minimally invasive technique to identify metastasis.
- Accurate sentinel lymph node identification is crucial for staging and treatment planning.
Purpose of the Study:
- To assess the feasibility of pre-operative lymphoscintigraphy.
- To evaluate radio-guided surgery for sentinel lymph node (SLN) detection in endometrial cancer.
- To determine the efficacy of intramyometrial 99mTc-nanocolloid administration for SLN biopsy.
Main Methods:
- Prospective study involving 33 endometrial cancer patients.
- Intramyometrial injection of 99mTc-nanocolloid followed by lymphoscintigraphy.
- Radio-guided surgery using a gamma probe for SLN identification and removal.
Main Results:
- Sentinel lymph nodes were identified in 79% of patients.
- A mean of 2.9 SLNs were detected per patient.
- Histopathology confirmed metastases in 7% of removed lymph nodes, with no false negatives observed.
Conclusions:
- Pre-operative lymphoscintigraphy and radio-guided surgery are effective for SLN identification in endometrial cancer.
- This method aids in accurate staging and can guide surgical management.
- The technique demonstrates high sensitivity for detecting metastatic sentinel lymph nodes.
