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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

[NASH in children]

Shinobu Ida1, Norikazu Yoshimura

  • 1Department of Pediatric Gastroenterology, Nutrition and Endocrinology, Osaka Medical Center and Research Institute for Maternal and Child Health.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 14, 2006
PubMed

Insights

Obese children can develop fatty liver disease, a condition that may progress to nonalcoholic steatohepatitis (NASH). Visceral fat, not just BMI, is linked to fatty liver and may reveal NASH mechanisms.

Area of Science:

  • Pediatric Gastroenterology and Hepatology
  • Metabolic Disorders
  • Obesity Research

Context:

  • Hepatic steatosis (fatty liver) is prevalent in obese children, mirroring adult conditions.
  • Fatty liver can progress to necro-inflammation, fibrosis, steatohepatitis, and cirrhosis.
  • Nonalcoholic steatohepatitis (NASH) is recognized in children, potentially linked to insulin resistance.

Purpose:

  • To explore the pediatric nonalcoholic steatohepatitis (NASH) etiology beyond obesity.
  • To investigate the role of adipose tissue distribution, particularly visceral adiposity, in pediatric fatty liver.
  • To understand the relationship between serum ALT, visceral adiposity, and BMI in children.

Summary:

  • Visceral fat adiposity increases fatty liver risk due to direct free fatty acid transport to the liver.
  • A stronger correlation was observed between serum ALT levels and visceral adiposity compared to BMI.
  • Other metabolic diseases like Wilson's disease, NICCD, OTC deficiency, and carnitine deficiency are associated with steatohepatitis and cirrhosis, offering insights into NASH progression.

Impact:

  • Highlights the significance of visceral adiposity in pediatric fatty liver disease.
  • Suggests potential mechanisms for NASH development in children.
  • Underscores the need for further research into the multifactorial causes of pediatric NASH.

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