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[NASH in children].

Shinobu Ida¹, Norikazu Yoshimura

¹Department of Pediatric Gastroenterology, Nutrition and Endocrinology, Osaka Medical Center and Research Institute for Maternal and Child Health.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|June 14, 2006

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Obese children can develop fatty liver disease, a condition that may progress to nonalcoholic steatohepatitis (NASH). Visceral fat, not just BMI, is linked to fatty liver and may reveal NASH mechanisms.

Area of Science:

Pediatric Gastroenterology and Hepatology
Metabolic Disorders
Obesity Research

Context:

Hepatic steatosis (fatty liver) is prevalent in obese children, mirroring adult conditions.
Fatty liver can progress to necro-inflammation, fibrosis, steatohepatitis, and cirrhosis.
Nonalcoholic steatohepatitis (NASH) is recognized in children, potentially linked to insulin resistance.

Purpose:

To explore the pediatric nonalcoholic steatohepatitis (NASH) etiology beyond obesity.
To investigate the role of adipose tissue distribution, particularly visceral adiposity, in pediatric fatty liver.
To understand the relationship between serum ALT, visceral adiposity, and BMI in children.

Summary:

Visceral fat adiposity increases fatty liver risk due to direct free fatty acid transport to the liver.

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A stronger correlation was observed between serum ALT levels and visceral adiposity compared to BMI.

Other metabolic diseases like Wilson's disease, NICCD, OTC deficiency, and carnitine deficiency are associated with steatohepatitis and cirrhosis, offering insights into NASH progression.

Impact:

Highlights the significance of visceral adiposity in pediatric fatty liver disease.
Suggests potential mechanisms for NASH development in children.
Underscores the need for further research into the multifactorial causes of pediatric NASH.