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[Immunomediation or hyperviscosity in rapidly progressive sensorineural hearing loss. A therapeutic approach]
F J García Callejo1, J B Ramírez Sabio, N Conill Tobías
1Servicio de Otorrinolaringología, Hospital Clínico Universitario de Valencia. jgarciacall@hotmail.com
Introduction:
To evaluate the therapeutic response and the rheologic and immunological characteristics in subjects bearing of rapidly progressive sensorineural hearing loss (RPSHL).
Patients And Methods:
A comparative prospective study on three groups of damaged ears treated with piracetam (n=29), corticosteroids (n=32) and plabcebo (n=25). Hearing loss and recovery level, whole blood filterability (WBF) and a Western-blot (WB) to anticochlear antibodies were evaluated.
Results:
Recovery average was 20,8 +/- 55,9% in the first group, with progressive of deafness in the rest (p<0,01). WB did not show differences among groups. The higher WBF at the end of therapy was detected on group 1 (20,36 +/- 2,54 Vs 18,42 +/- 3,42 microl/seg on group 3; p<0,05). Moreover, it impaired only on those treated with piracetam, with statistically significative differences over the other two groups.
Conclusions:
We detected alterations on WBF in patients with RPSHL that justify the use of rheoactive measures as a pathophysiological therapy.
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