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Updated: Aug 7, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Advances in the adjuvant treatment of colorectal cancer
Ina C Nordman1, Shoba Iyer, Anthony M Joshua
1Department of Medical Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Background:
There have been numerous advances in the adjuvant therapy of colon cancer in the last two decades.
Methods:
This review outlines the historical perspectives of adjuvant treatment as well as current and emerging standards of care.
Results:
Although previous regimens included a variety of equivalent schedules of 5-fluorouracil and folinic acid, integration of newer drugs such as oxaliplatin are offering significant improvements in disease-free survival. The use of targeted agents such as bevacuzimab creates the potential to further increase cure rates in the adjuvant setting. The current low rate of referral of eligible patients for chemotherapy in Australia is also discussed.
Conclusion:
Adjuvant therapy for colon cancer is making major strides as we attempt to cure more patients.
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