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Updated: Aug 7, 2026

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
Published on: September 11, 2012
[Does 5-ASA prevent development of colon cancer in ulcerative colitis?]
1Arhus Universitetshospital, Aalborg Sygehus, Medicinsk Gastroenterologisk Afdeling. u19017@aas.nja.dk
Abstract:
Several case control studies have demonstrated that in patients with ulcerative colitis, ingestion of 5-ASA is correlated with a reduced risk of developing colon cancer. A recent editorial in The American Journal of Gastroenterology concluded that "a 5-ASA tablet a day keeps the cancer away". However, the clinical studies in the meta-analysis upon which this conclusion is based are relatively small, and confounding could explain the observed correlation. A large study in which a chemoprotective effect of 5-ASA could not be found has been presented but has not yet been published. It would be advisable to wait for further documentation before 5-ASA is prescribed for chemo prevention of colonic cancer.
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