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Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis
Yue Fang1, Fernando Rivadeneira, Joyce B J van Meurs
1Department of Internal Medicine, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
Introduction:
Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting.
Materials And Methods:
We searched published studies from 1996 to September 2005 through PubMed and evaluated the genetic effect of the BsmI and TaqI polymorphism of VDR on fracture risk in a meta-analysis. Thirteen studies with a total of 20 eligible comparisons (1632 fracture cases and 5203 controls) were analyzed with fixed and random effects models.
Result:
No evidence of relationship between the VDR BsmI or TaqI polymorphism and fracture risk was observed with any genetic model. The odds ratio (95% confidence interval) of b-allele versus B-allele was 0.98 (0.86-1.12) with random effects calculations. There was significant between-study heterogeneity. Small studies did not differ significantly from larger ones.
Conclusion:
No relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data.
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