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Related Experiment Videos

Analysis of clustered data in multicentre trauma studies.

Bahman Roudsari1, Avery Nathens, Thomas Koepsell

  • 1Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA, USA. roudsari@u.washington.edu

Injury
|June 14, 2006
PubMed
Summary

The Intraclass Correlation Coefficient (ICC) for emergency department shock and in-hospital trauma fatality rates are low, but crucial for designing multicenter studies. Awareness of these ICCs is vital for accurate sample size calculations in trauma research.

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Area of Science:

  • Trauma research
  • Clinical study design
  • Biostatistics

Background:

  • Designing multicenter studies requires estimating the correlation of observations within centers.
  • The Intraclass Correlation Coefficient (ICC) is a standard measure for this correlation.

Purpose of the Study:

  • To calculate the ICC for in-hospital trauma fatality and emergency department (ED) shock rate.
  • To assess the influence of these ICCs on sample size and statistical power in trauma research.

Main Methods:

  • Utilized the National Trauma Data Bank (NTDB) with over 1.2 million records from 448 trauma centers.
  • Calculated ICCs for ED shock and in-hospital fatality rates in patients directly transported from injury scenes to Level I or II trauma centers.

Main Results:

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  • The ICC for ED shock rate was 0.010, and for in-hospital fatality rate was 0.039.
  • Penetrating injuries showed higher ICCs for both shock and fatality compared to blunt injuries.
  • The ICC for ED shock was lowest in women, though not statistically significant compared to men.

Conclusions:

  • While ICC values were small, they significantly impact sample size and power in cluster-based studies.
  • Investigators must consider these ICCs to ensure adequate sample sizes and robust study designs in trauma research.